| Date | Game | Location | Time (EST) | TV | Tickets |
|---|---|---|---|---|---|
| Sept. 4, 2010 | Notre Dame vs Purdue | South Bend, Ind. | 3:30 p.m. | NBC | Tickets |
| Sept. 11, 2010 | Notre Dame vs Michigan | South Bend, Ind. | 3:30 p.m. | NBC | Tickets |
| Sept. 18, 2010 | Notre Dame at Michigan State | East Lansing, Mich. | TBA | TBA | Tickets |
| Sept. 25, 2010 | Notre Dame vs Stanford | South Bend, Ind. | 3:30 p.m. | NBC | Tickets |
| Oct. 2, 2010 | Notre Dame at Boston College | Chestnut Hill, Mass. | TBA | TBA | Tickets |
| Oct. 9, 2010 | Notre Dame vs Pittsburgh | South Bend, Ind. | 3:30 p.m. | NBC | Tickets |
| Oct. 16, 2010 | Notre Dame vs Western Michigan | South Bend, Ind. | 2:30 p.m. | NBC | Tickets |
| Oct. 23, 2010 | Notre Dame at Navy | East Rutherford, N.J. | TBA | TBA | Tickets |
| Oct. 30, 2010 | Notre Dame vs Tulsa | South Bend, Ind. | 2:30 p.m | NBC | Tickets |
| Nov. 13, 2010 | Notre Dame vs Utah | South Bend, Ind. | 2:30 p.m | NBC | Tickets |
| Nov. 20, 2010 | Notre Dame vs Army | Bronx, N.Y. (Yankee Stadium) | 7:00 p.m. | NBC | Tickets |
| Nov. 27, 2010 | Notre Dame at USC | Los Angeles, Calif. | TBA | TBA | Tickets |
| TBA | Bowl Game | TBA | TBA | TBA | |
2010 Notre Dame Home Games: Purdue (9/4), Michigan (9/11), Stanford (9/25), Pitt (10/9), Tulsa (10/30), Utah (11/13), Navy at Yankee Stadium (11/20)
2010 Notre Dame Away Games: Michigan State (9/18), Boston College (10/2), Navy at East Rutherford, NJ (10/23), USC (11/27)
